318 Supplement Since the publication of the 4th German edi tion (1987) new results have been gained, which are detailed in the following three origi nal papers Nos. 373, 374, 375 and 380 of our publication list. It has been found that there are two basic types of action of oxygen multistep therapy. In specific studies using mostly large numbers of individuals, the efficacy of the oxygen multi- step therapy and oxygen multistep immuno stimulation has been demonstrated by the im provement of about 30 physiological parameters (primary and secondary effects). There are only few therapeutic regimens in the history of medicine, the positive effects of which could or can be proven by measuring of numerous para meters. In the long run, scientific truth has prevailed over methodological errors and pre judice. The consideration of the human body in terms of physical energy and its dynamics may be strange in established medicine, but is never theless obvious. Since 1987 the author has passed more and more on to considering general issues of the human body and life, as well as the problems of illness, immune defense, therapeutic effects, health and age, from an energetic point of view. New findings have resulted in supplementing the definition of the oxygen status (arterial oxygen partial pressure Po2-art, at rest; venous oxygen partial pressure Po2-yen, at rest; value of n; O2 uptake at rest; maximum O2 uptake) by ergometric measurements of the energetic status (charge maximum during 2 min, PWC test). Several more detailed explanations of the energetic status of man, the deterioration of this status with progressing age, the energy con sumption by illness and stress, as well as of the improvement of the energetic state and, hence, the energetic reserves by means of physical exercise and oxygen multistep therapy are given. Studies of the proportionality between the energetic state and the cancer cell-killing capacity of the defense mechanisms of the body have made it reasonable to report in more detail on the different concepts of combatting cancer by using the oxygen multistep immuno stimulation. Many clinical results obtained by our medical partners and ourselves indicate that these concepts will become an indispensable element of future anticancer strategies. Note that each part of the supplement has its own reference list. Dresden Weisser Hirsch, July 1988 Manfred von Ardenne